Researchers develop novel algorithm to unlock role of cellular phenomenon in aggressive cancers

Scientists at The Hospital for Sick Children (SickKids) have developed a novel computational tool to directly measure hypertranscription in tumour cells, a feature present in almost all cases of human cancer, with novel implications for treatment strategies.

In the study published in Science Advances, researchers developed a new algorithm called RNAmp to examine over 7,000 tumours spanning 31 cancer types and demonstrated hypertranscription is present across most cancers. Hypertranscription is a unique phenomenon that occurs when transcription, the process by which new RNA molecules are created, is increased leading to elevated RNA output across the entire genome.

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