Tech #1035: The Index for Clinical Assessment of Post-Thrombotic Syndrome in Children (CAPTSure)
CAPTSure is a novel clinical assessment tool designed to diagnose and quantify the severity of post-thrombotic syndrome in children with a history of deep vein thrombosis. Developed through international patient and expert input and validated in at-risk pediatric populations, it captures both clinician-observed signs and patient-reported symptoms, providing a more comprehensive and meaningful measure of disease burden.
Technology Reference Number
#1035
Inventors
IP&C Contact
Therapeutic Area
Deep Vein Thrombosis
Category
Health Outcome Measure
Keywords
CAPTSure, post-thrombotic syndrome (PTS), pediatric thrombosis, deep vein thrombosis (DVT), clinical assessment tool, severity scoring, patient-reported outcomes, clinician-assessed indicators
Invention Description
Post-Thrombotic Syndrome (PTS) is a long-term complication of venous blood clots (thrombosis). Our group conducted a series of studies that aimed to develop a measurement tool to diagnose and determine the severity of PTS affecting the arms or legs of children who had a deep vein thrombosis.
To develop the new tool entitled the Index for Clinical Assessment of Post-Thrombotic Syndrome in Children (CAPTSure) we first gathered signs and symptoms relevant to PTS from patients and pediatric thrombosis experts, and later piloted each one of these signs and symptoms in children at risk of PTS (i.e., children with venous clots in their arms or legs). We then asked experts to use the information we collected and their clinical experience to choose which signs and symptoms should remain in the new tool.
There are several differences with the existing tools: 1) we developed this tool with the participation of an international panel of patients and pediatric thrombosis experts; 2) the tool measured PTS separately for arms and a for legs, as it is possible that clinical manifestations are different between them; 3) following the opinion of experts, CAPTSure assesses more symptoms than current pediatric tools; 4) each item of the tool (signs and symptoms) is scored based on its importance; a higher final score represents worse or more severe PTS; and 5) the final score has been shown to be convey meaningful information in the pediatric setting.
The tool has two components: one for patients to complete (symptoms) and the other for clinicians (signs). The patient portion contains graphics that assist in understanding the questions.
Advantages
- This tool provides guidance to clinicians on the diagnosis and severity rating of PTS in pediatric patients.
- We are integrating the tool in EPIC; the patient reporting component has been fully developed.
Additional Information
As with any clinical tool, the results should always be interpreted by a physician.
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