Tech #4029: Canadian Haemophilia Outcomes – Kids’ Life Assessment Tool (CHOK-LAT)

The Canadian Haemophilia Outcomes – Kids’ Life Assessment Tool (CHO-KLAT) v3.0 is a validated, 41-item haemophilia-specific questionnaire that measures health-related quality of life in boys aged 4 to 18, capturing how the condition affects daily play, school, and feelings. Available in child and caregiver report versions and multiple languages, it incorporates subdomain scoring to assess concepts relevant to emerging therapies, such as burden of administration.

Technology Reference Number

#4029

Inventors

Nancy Young, The Hospital for Sick Children

IP&C Contact

Karin Aguilar, Business Development Associate

Therapeutic Area

Hemophilia/Haemophilia

Category

Health Outcome Measure

Keywords

Paediatric haemophilia, Health-related quality of life (HRQoL), CHO-KLAT, Child-reported outcome, Caregiver-reported outcome, Validated clinical tool, Child-centric assessment, Emerging therapies

Invention Description

The Canadian Haemophilia Outcomes – Kids’ Life Assessment Tool (CHO-KLAT) v.3.0  is a 41-item haemophilia-specific health-related quality of life (HRQoL) questionnaire with a child report version (ages 7 to 18) and caregiver report version.

The CHO-KLAT was  initially developed in 2004 when disease specific HRQoL measures were lacking, and the generic measures used did not usually focus on children’s perspectives. In 2008,  linguistic translation and cognitive debriefing to develop versions of the CHO-KLAT in France, Germany, The Netherlands, Spain, and the United Kingdom led to slight modifications, resulting in the the CHO-KLAT version 2.0 (CHO-KLAT v2.0).

In a follow-up study, the relevance of the item content of the CHO-KLAT v2.0 was reviewed in the context of extended half-life clotting factor concentrates (EHL CFCs) and other emerging non-factor therapies. The CHO-KLAT v3.0 is a valid, reliable child-centric tool that is designed to measure HRQoL among boys with haemophilia and incorporates a subdomain scoring structure to facilitate assessment of concepts important to emerging therapies, such as burden of administration.

Advantages

  • Evaluates how haemophilia affects daily play, school and feelings
  • Patients or parents can complete the survey
  • Validated for boys aged 4 to 18
  • Available in multiple languages

Additional Information

 

Copyright © The Hospital for Sick Children, Dr. Victoria Price, University of Manitoba and Laurentian University, 2006

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